From The Atlantic: What ketamine does to the human brain

Last month, during Elon Musk’s appearance at the Conservative Political Action Conference, as he hoisted a chain saw in the air, stumbled over some of his words, and questioned whether there was really gold stored in Fort Knox, people on his social-media platform, X, started posting about ketamine.

Musk has said he uses ketamine regularly, so for the past couple of years, public speculation has persisted about how much he takes, whether he’s currently high, or how it might affect his behavior. Last year, Musk told CNN’s Don Lemon that he has a ketamine prescription and uses the drug roughly every other week to help with depression symptoms. When Lemon asked if Musk ever abused ketamine, Musk replied, “I don’t think so. If you use too much ketamine you can’t really get work done,” then said that investors in his companies should want him to keep up his drug regimen. Not everyone is convinced. The Wall Street Journal has reported that Musk also takes the drug recreationally, and in 2023, Ronan Farrow reported in The New Yorker that Musk’s “associates” worried that ketamine, “alongside his isolation and his increasingly embattled relationship with the press, might contribute to his tendency to make chaotic and impulsive statements and decisions.”

But hey, that was 2023. He doesn’t make any chaotic impulsive statements and decisions these days, right?

Ketamine is called a dissociative drug because during a high, which lasts about an hour, people might feel detached from their body, their emotions, or the passage of time. Frequent, heavy recreational use—say, several times a week—has been linked to cognitive effects that last beyond the high, including impaired memory, delusional thinking, superstitious beliefs, and a sense of specialness and importance.

So that’s why Musk thinks humans can live on Mars?

Research has not yet established the side effects of long-term ketamine therapy, but older studies of recreational users offer some insight on heavy, extended dosing. Celia Morgan, now a psychopharmacology professor at the University of Exeter, in England, led a 2010 study that followed 120 recreational ketamine users for a year. Even infrequent users—those who used, on average, roughly three times a month—scored higher on a delusional-thought scale than ex–ketamine users, people who took other drugs, and people who didn’t use drugs at all. Those who averaged 20 uses a month scored even higher. People believed that they were the sole recipients of secret messages, or that society and people around them were especially attuned to them.

Does that sound like Musk?

H/t Jim Baerg