A fundamental flaw in what it intends to discover
The whistleblowers provide much food for thought.
This passage about halfway through for instance:
The puberty blocker trial has a fundamental flaw in what it intends to discover. Young people experiencing intense distress about pubertal changes will understandably feel great relief when offered a way to halt them, and this relief may seem like successful treatment. However, the trial overlooks how the very prospect of medical intervention affects their mental state during assessment, and it fails to consider what this communicates: that their distress is unbearable instead of something they might be supported to work through. Many of these young people already struggle with their identity and experience a sense of not fitting in with most of their peers. Keeping them in developmental stasis for two years while their peer group matures around them does not provide a neutral pause; it further isolates them from a normal developmental path. While their friends face the social and psychological challenges of puberty, forming new relationships and shaping their adult identities, these young people remain frozen at an earlier stage. This divergence from their peers may worsen their difficulties rather than help, reinforcing their feeling that they cannot manage what their peers are handling, at the very moment when connecting with peers matters most.
And the thing is, these young people who remain frozen won’t be able to understand that fact until it happens. Their brains aren’t old enough yet. Infants don’t understand fairy tales, and 15-year-olds don’t know how they will think and feel at age 20. It’s a black box to them. So when the choice is between let maturation proceed even though it feels awkward and wrong, or halt maturation even though that will feel like a horrific mistake in 5 or 10 years, option number one seems at least less risky.

And the effects are not “100% reversible.” It’s not guaranteed that holding back pubertal development is “just a pause,” and that normal puberty can proceed once the blockers are stopped. The window of opportunity for normal maturation into adulthood is not open-ended. Halt puberty long enough, or at the critical period for this particular individual, and the chance can be lost forever. A person can end up without full maturation.
Puberty is not a disease. It’s a normal process that comes with changes. There’s no point in stopping puberty, just because you don’t like your developing body. It’s not as if a male can choose to have anything other than a male puberty. He’s never going to have a female puberty. Same in the other direction. Girls who don’t like their developing female body are not able to wait for a male puberty to come along. The one and only puberty they will ever have is the female one. The only other option is to not mature. What kind of choice is that? Remain childlike and stunted, or grow up. Those are the only choices.