Despite a lack of empirical evidence that 12-step programs work

Katie Herzog at The Stranger reports on a medication for alcohol addiction that – unlike 12-step programs – works.

Alcohol addiction is often thought of in recovery circles like AA as a moral failing, something that can be treated if you just try, and believe, hard enough. This, however, is contrary to what most research tells us about how alcohol works on human beings. Morality, if you ask scientists, has nothing to do with it.

Rather, alcohol is primed to be addictive. After it is absorbed into the bloodstream, it soon moves to the brain, where it impacts several chemicals, or neurotransmitters, including gamma-aminobutyric acid (or GABA), glutamate, and dopamine (the so-called “pleasure molecule”). The combined effect of these chemicals is that you let go of inhibitions, feel euphoric, and become relaxed but energized at the same time. It feels good in both your mind and body—at least in the beginning.

(Subjective aside – it doesn’t for me. A glass of wine is ok, but more than that is unpleasant, and euphoria is never really in the picture. I’m profoundly content with this situation, because alcohol addiction cut a wide swathe through my family.)

After repeated exposure to alcohol, things start to change: The brain starts to produce less dopamine and GABA and more glutamate. This tends to make people anxious, irritable, and depressed. You get sick and go through withdrawal. In time, you don’t drink because it feels good, you drink because not drinking starts to feel awful.

The physical effects of ongoing drinking are serious. Besides damaging major organs from the heart to the liver, long-term heavy alcohol use can do terrifying things to the mind.

Like destroying the ability to form new memories. Oh goody, artificial dementia!

Enter Naltrexone, which blocks endorphins from the brain.

The Sinclair Method, as the protocol is known, is simple: You take Naltrexone one hour before you start drinking, each and every time you drink (and preferably not on an empty stomach). Instead of feeling that familiar euphoric buzz, drinking just makes you feel kind of sloppy and muddy-headed.

With Naltrexone, “alcohol becomes non-reinforcing,” said Brian Noonan, a psychiatric nurse practitioner and the owner of Ballard Psychiatric Services. “With repeated trials of drinking without reward, the association of drinking with reward begins to extinguish.” The patient starts drinking less and less often. Some eventually stop altogether.

But AA still has a death grip on alcoholism treatment in the US, despite the fact that its success rate is abysmal.

AA and abstinence are still the only models most doctors in the US are taught, despite a lack of empirical evidence that 12-step programs work. Perhaps more would be interested in medicines like Naltrexone, but most have never even heard of the Sinclair Method—which, as far as I’ve been able to find, isn’t taught in any American medical schools. More than one Naltrexone patient told me they get their drugs through an online pharmacy based in India because their doctors just don’t know anything about it.

That’s millions of lives made worse that don’t need to be.

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